The answer came while studying the work of Dr. Patricia Kane and Ed Kane. Watch Ed talk about his recovery from significant memory decline.
Could we reduce overall inflammation using Essential Fatty Acids? The answer is YES! The biochemistry gets a little sticky but don't give up.
By the way, Essential means the body has no way to make the chemical -it must be eaten.
The inflammatory pathways have been mapped out in some detail. NSAIDS (non-steroidal anti inflammatories) like Ibuprofen cut the inflammatory pathway at the COX 1 and COX-2 enzymes.
“Arachidonic acid (AA) is metabolized by COX-1 and COX-2 enzymes to form a mesmerizing array of biologically active products (NSAIDS, aspirin etc, block this conversion). These, in turn, are acted on by isomerases and synthases to form the Prostaglandins (PGs) and thromboxane A2” (Grosser 200639). “Recently, our understanding of all these activated products has been transformed and is changing our perception of prostanoid biology” (Funk 200540). NSAIDs are among the most commonly used drugs to relieve pain and inflammation by suppressing the COX function of forming PGs, which has the role of forming two opposing prostanoids, that of PGE2 and prostacyclin (PGI2)40 (Murata41). “The biological effects of these two prostaglandins are generally antagonistic to each other.
PGE2 is *pro-inflammatory, induces proliferation, and is anti-apoptotic.
PGI2 is *anti-inflammatory, a strong vasodilator, an inhibitor of growth of vascular smooth muscle cells, and a potent inhibitor of platelet aggregation”(Garcia Rodriguez 200742).
In other words, the body has a system to clean up the inflammation if we give the body what it needs to make these anti-inflammatory chemicals.
The Body Bio Balanced oil has the right ratio of omega 6 to omega 3 to create these anti inflammatory products. It is the precursor to Arachidonic Acid and DHA. But there is no problem taking DHA (fish oil) or eating AA which is found in eggs and butter.
A whole new world of anti-inflammatory aids from Arachidonic Acid, Eicosapentaenoic (EPA) and Docahexanoic Acid (DHA) called Resolvins, are a recently discovered natural anti-inflammatory hormone-type prostanoids. They search out the specific inflammation, such as asthma or arthritis and directly reverse the inflammation.
Resolvins resolve it directly, hence the name --- the asthma or arthritis is relieved.
It is included in this protocol to try to directly resolve the inflammation in the brain that leads to degeneration.
It’s a natural and direct action derived from the body’s own lipid reservoir – that is why the essential precursors in the Body Bio Balanced Oil is included. This is far more desirable than an indirect (body wide) NSAID or steroid form of relief or taking an antibiotic like Minocycline for life. [Link to study using Minocycline to lower inflammation in the DS mouse.]
Resolvins were discovered by Harvard researcher Charles Serhan in 1984, over 20 years ago.